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ICEC 0942 hydrochloride

CAS No. 1805789-54-1

ICEC 0942 hydrochloride ( —— )

Catalog No. M12760 CAS No. 1805789-54-1

ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ICEC 0942 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
  • Description
    ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM); displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9; demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM; shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.Solid Tumors Phase 1 Clinical
  • Synonyms
    ——
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    1805789-54-1
  • Formula Weight
    430.98
  • Molecular Formula
    C22H31ClN6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : ≥ 62.5 mg/mL 145.02 mM
  • SMILES
    CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCC4CCNCC4O.Cl
  • Chemical Name
    (3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.
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