ICEC 0942 hydrochloride ( —— )

Catalog No. M12760 CAS No. 1805789-54-1

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Product Name

ICEC 0942 hydrochloride
Note

Research use only, not for human use.
Brief Description

ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM).
Description

ICEC 0942 (CT7001) is a potent, selective, orally active CDK7 inhibitor with IC50 of 41 nM, displays 15-fold selectivity over CDK2 (IC50=578 nM); displays 45-, 15-, 230- and 30-fold selectivity over CDK1, CDK2, CDK5 and CDK9; demonstrates sensitivity against a wide range of cancer types with GI50 values ranging between 0.2-0.3 uM; shows substantial anti-tumor effects in xenografts of both breast and colorectal cancers, also exhibits complete growth arrest of ER-positive tumor xenografts combined with tamoxifen.Solid Tumors Phase 1 Clinical
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

Cancer
Indication

Solid Tumors

CAS Number

1805789-54-1
Formula Weight

430.98
Molecular Formula

C22H31ClN6O
Purity

>98% (HPLC)
Solubility

DMSO : ≥ 62.5 mg/mL 145.02 mM
SMILES

CC(C)C1=C2N=C(C=C(N2N=C1)NCC3=CC=CC=C3)NCC4CCNCC4O.Cl
Chemical Name

(3R,4R)-4-(((7-(benzylamino)-3-isopropylpyrazolo[1,5-a]pyrimidin-5-yl)amino)methyl)piperidin-3-ol hydrochloride

1. Hazel P, et al. ChemMedChem. 2017 Mar 7;12(5):372-380.
2. Patel H, et al. Mol Cancer Ther. 2018 Mar 15. pii: molcanther.0847.2016.

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